Embodiments herein relate to a method performed by a radio network node for enabling communication for a wireless device in a communication network, which communication network comprises a core network with partitioned sets of functionalities, where a first core network node supports a first set of functionalities out of a total set of functionalities in the core network, and the first set of functionalities belongs to a first network slice of the core network and is separated from another set of functionalities. The radio network node receives a connection request from the wireless device comprising an indication, which indication indicates connection to the first network slice. The radio network node retrieves configuration information from a network node for establishing the connection interface, for RAN and/or CN, to the first network slice, and establishes the connection interface towards the first core network node using the retrieved configuration information.