A shoe may include an upper portion constructed from a continuous textile (e.g., a knit textile) that includes multiple regions having different textile properties to improve the performance of the shoe, including durability and comfort. In some cases, the multi-region upper portion may include regions having different thickness and/or flexibility based on a location relative to a wearer's foot to better support the wearer's foot. For example, the multi-region upper portion may include a reinforcement region having a first thickness and a flex region having a second thickness less than the first thickness. As another example, the multi-region upper portion may include a reinforcement region having a first stiffness and a flex region having a second stiffness less than the first stiffness.