Invention Grant
- Patent Title: Method for producing Hib conjugate vaccine using PRP with lowered molecular weight
-
Application No.: US16340778Application Date: 2017-10-11
-
Publication No.: US11027005B2Publication Date: 2021-06-08
- Inventor: Makoto Moriyama , Katsuhiko Fukada , Kazuhiko Kimachi , Yuki Mihara , Hiroshi Yonemura , Yoichiro Kino
- Applicant: KM Biologies Co., Ltd.
- Applicant Address: JP Kumamoto
- Assignee: KM Biologies Co., Ltd.
- Current Assignee: KM Biologies Co., Ltd.
- Current Assignee Address: JP Kumamoto
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JPJP2016-206033 20161020
- International Application: PCT/JP2017/036781 WO 20171011
- International Announcement: WO2018/074296 WO 20180426
- Main IPC: A61K39/385
- IPC: A61K39/385 ; A61K39/102 ; A61P31/16 ; A61K39/00
Abstract:
A method for preparing a PRP conjugate having high storage stability and a method for producing a Hib conjugate vaccine are provided. A method for preparing PRP conjugate in accordance with the embodiments of the present invention is characterized by that the release of PRPs after preparing the PRP conjugate is suppressed by using PRP with a lowered molecular weight than native PRP for a coupling reaction between PRP and a carrier protein. Also, a Hib conjugate vaccine comprising as an antigen the PRP conjugate prepared by said method has excellent storage stability and maintain sufficient immunogenicity.
Public/Granted literature
- US20200046822A1 METHOD FOR PRODUCING Hib CONJUGATE VACCINE USING PRP WITH LOWERED MOLECULAR WEIGHT Public/Granted day:2020-02-13
Information query
