Invention Grant
- Patent Title: Recombinant mumps virus vaccine
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Application No.: US16352135Application Date: 2019-03-13
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Publication No.: US11027008B2Publication Date: 2021-06-08
- Inventor: Biao He , Steven A. Rubin
- Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , The United State of America, as represented by the Secretary, Department of Health and Human Services, Food and Drug Administration
- Applicant Address: US GA Athens; US MD Silver Spring
- Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.,The United State of America, as represented by the Secretary, Department of Health and Human Services, Food and Drug Administration
- Current Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.,The United State of America, as represented by the Secretary, Department of Health and Human Services, Food and Drug Administration
- Current Assignee Address: US GA Athens; US MD Silver Spring
- Agency: Mueting Raasch Group
- Main IPC: A61K39/165
- IPC: A61K39/165 ; A61K39/12 ; A61K39/155 ; C07K16/10 ; C07K16/24 ; C12N7/00 ; A61K39/00
Abstract:
The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuVIowa/US/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to rMuVIowa/US/06 and JL vaccine viruses. Such constructs include viral constructs lacking the open reading frame (ORF) of the SH gene (rMuVΔSH) and/or incapable of expressing the V protein (rMuVΔV).
Public/Granted literature
- US20190216918A1 RECOMBINANT MUMPS VIRUS VACCINE Public/Granted day:2019-07-18
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