A vehicle body structure has: a front plate portion that faces in a vehicle front-rear direction; an inclined portion that obliquely descends rearward from a lower end of the front plate portion and is coupled to a floor panel making up a floor surface of a cabin; an arch-shaped portion located at outer end portions in a vehicle width direction of the front plate portion and the inclined portion and makes up a wheel arch-shaped rear portion of a tire house; a front side frame located inward of the arch-shaped portion in the vehicle width direction and extends from the front plate portion to the inclined portion in the vehicle front-rear direction; and a reinforcement panel placed over the arch-shaped portion. The reinforcement panel is disposed outward in the vehicle width direction of an innermost portion in the vehicle width direction in the arch-shaped portion.