- Patent Title: Crystalline forms of ozanimod and processes for preparation thereof
-
Application No.: US16326353Application Date: 2017-08-18
-
Publication No.: US11028060B2Publication Date: 2021-06-08
- Inventor: Minhua Chen , Yanfeng Zhang , Xiaoting Zhai , Kaiqiang Yan , Chaohui Yang , Xiaoyu Zhang
- Applicant: RECEPTOS LLC
- Applicant Address: US NY New York
- Assignee: RECEPTOS LLC
- Current Assignee: RECEPTOS LLC
- Current Assignee Address: US NY New York
- Agency: McCarter & English, LLP
- Agent Wei Song
- Priority: CN201610687206.5 20160819,CN201610822328.0 20160914
- International Application: PCT/CN2017/098125 WO 20170818
- International Announcement: WO2018/033149 WO 20180222
- Main IPC: A61K31/4245
- IPC: A61K31/4245 ; C07D271/06 ; A61P25/00 ; A61P1/04 ; A61P1/00 ; A61P37/02

Abstract:
The present disclosure relates to novel crystalline forms of ozanimod and preparation method thereof. The provided crystalline forms of ozanimod comprise crystalline form CS9, crystalline form CS10 and crystalline form CS11, and can be used for treating autoimmune diseases, particularly used for preparing drugs for treating multiple sclerosis and ulcerative colitis. The crystalline forms of the present disclosure have one or more advantages in solubility, stability, hygroscopicity and processability and provide new and better choices for the preparation of ozanimod drug product, and are very valuable for drug development.
Public/Granted literature
- US20200216404A1 CRYSTAL FORMS OF OZANIMOD AND PREPARATION METHOD THEREFOR Public/Granted day:2020-07-09
Information query