Invention Grant
- Patent Title: Salt of substituted piperidine compound
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Application No.: US16472000Application Date: 2017-12-22
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Publication No.: US11028069B2Publication Date: 2021-06-08
- Inventor: Morihiro Mitsuya
- Applicant: TAIHO PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Chiyoda-ku
- Assignee: TAIHO PHARMACEUTICAL CO., LTD.
- Current Assignee: TAIHO PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Chiyoda-ku
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JPJP2016-249767 20161222
- International Application: PCT/JP2017/046249 WO 20171222
- International Announcement: WO2018/117267 WO 20180628
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K9/00 ; A61P35/00

Abstract:
An object of the present invention is to provide a salt of the compound 1-(2,3-dichlorobenzoyl)-4-((5-fluoro-6-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2-yl)methyl)piperidine-4-carboxylic acid, useful as an antitumor agent, and crystals thereof which are excellent in solubility, stability, and oral absorption and can be produced in large quantities. The present invention relates to a hydrochloride salt of 1-(2,3-dichlorobenzoyl)-4-((5-fluoro-6-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2-yl)methyl)piperidine-4-carboxylic acid and crystals of the hydrochloride salt having characteristic peaks at particular diffraction angles in powder X-ray diffraction spectrum.
Public/Granted literature
- US20200087282A1 SALT OF SUBSTITUTED PIPERIDINE COMPOUND Public/Granted day:2020-03-19
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