Invention Grant
- Patent Title: Pyrimido-diazepinone kinase scaffold compounds and methods of treating DCLK1/2-mediated disorders
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Application No.: US16343102Application Date: 2017-10-18
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Publication No.: US11028089B2Publication Date: 2021-06-08
- Inventor: Fleur M. Ferguson , Nathanael S. Gray
- Applicant: DANA-FARBER CANCER INSTITUTE, INC.
- Applicant Address: US MA Boston
- Assignee: DANA-FARBER CANCER INSTITUTE, INC.
- Current Assignee: DANA-FARBER CANCER INSTITUTE, INC.
- Current Assignee Address: US MA Boston
- Agency: Burns & Levinson, LLP
- Agent Daniel W. Clarke
- International Application: PCT/US2017/057126 WO 20171018
- International Announcement: WO2018/075608 WO 20180426
- Main IPC: A61K31/551
- IPC: A61K31/551 ; A61P35/00 ; C07D487/04
Abstract:
The present invention relates to use of pyrimido-diazepinone compounds that are able to modulate protein kinases such as doublecortin-like kinase (DCLK1) and doublecortin-like kinase 2 (DCLK2), which are members of serine/threonine-protein kinase family and Ca2+/calmodulin-dependent protein kinase class of enzymes, and the use of such compounds in the treatment of various diseases, disorders or conditions.
Public/Granted literature
- US20190315753A1 PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DCLK1/2-MEDIATED DISORDERS Public/Granted day:2019-10-17
Information query
