Invention Grant
- Patent Title: Preparative scale conversion of gonyautoxins to neosaxitoxin
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Application No.: US17018816Application Date: 2020-09-11
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Publication No.: US11028094B2Publication Date: 2021-06-08
- Inventor: Andrew Ian Selwood , Roelof Van Ginkel , Craig Alan Waugh
- Applicant: THE CAWTHRON INSTITUTE TRUST BOARD
- Applicant Address: NZ Nelson
- Assignee: THE CAWTHRON INSTITUTE TRUST BOARD
- Current Assignee: THE CAWTHRON INSTITUTE TRUST BOARD
- Current Assignee Address: NZ Nelson
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
- Main IPC: C07D487/14
- IPC: C07D487/14
Abstract:
A method of preparing neosaxitoxin in quantities of a purity sufficient to allow the compound to be used as an active pharmaceutical ingredient (API) is described. The method includes the reductive desulfonation of an unresolved mixture of gonyautoxin 1 (GTX1) and gonyautoxin 4 (GTX4).
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