Invention Grant
- Patent Title: 4-phenylpiperidines, their preparation and use
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Application No.: US16151019Application Date: 2018-10-03
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Publication No.: US11028098B2Publication Date: 2021-06-08
- Inventor: Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agent John P. White; Gary J. Gershik
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D471/04 ; C07D487/04 ; C07D495/04 ; A61P27/02 ; C07D401/06 ; C07D405/14 ; C07D409/06 ; C07D491/052

Abstract:
The present invention provide a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterocycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20190031681A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE Public/Granted day:2019-01-31
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