Invention Grant
- Patent Title: Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
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Application No.: US16160846Application Date: 2018-10-15
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Publication No.: US11028126B2Publication Date: 2021-06-08
- Inventor: Stephen James Moore , Margaret Thy Luu Nguyen , Daniel Robert Hostetter , Olga Vasiljeva
- Applicant: CytomX Therapeutics, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: CytomX Therapeutics, Inc.
- Current Assignee: CytomX Therapeutics, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- Main IPC: C07K7/06
- IPC: C07K7/06 ; A61K47/65 ; A61K47/68 ; C07K7/08 ; C07K16/00 ; A61K49/00 ; C07K16/28 ; A61K39/00
Abstract:
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator (uPA), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator in a variety of therapeutic, diagnostic and prophylactic indications.
Public/Granted literature
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