Invention Grant
- Patent Title: ALK7:actriib heteromultimers and uses thereof
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Application No.: US16251935Application Date: 2019-01-18
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Publication No.: US11028145B2Publication Date: 2021-06-08
- Inventor: Ravindra Kumar , Asya Grinberg , Dianne Sako , Robert Scott Pearsall , Roselyne Castonguay , Gang Li , Yossi Dagon , John Knopf
- Applicant: Acceleron Pharma Inc.
- Applicant Address: US MA Cambridge
- Assignee: Acceleron Pharma Inc.
- Current Assignee: Acceleron Pharma Inc.
- Current Assignee Address: US MA Cambridge
- Agency: White & Case LLP
- Main IPC: C07K14/71
- IPC: C07K14/71 ; A61K38/00 ; A61K38/45 ; C12N9/12
Abstract:
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK7 receptor and an extracellular domain of ActRIIB In certain aspects, these ALK7:ActRIIB heteromultimers are can be used to improve metabolic parameters in a patient in need thereof. In certain aspects, these ALK7:ActRIIB heteromultimers are can be used to treat or prevent one or more kidney-associated disease or condition in a patient in need thereof.
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