Invention Grant
- Patent Title: Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS
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Application No.: US15982990Application Date: 2018-05-17
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Publication No.: US11028156B2Publication Date: 2021-06-08
- Inventor: William M. Pardridge , Ruben J. Boado
- Applicant: ARMAGEN, INC.
- Applicant Address: US CA Calabasas
- Assignee: ARMAGEN, INC.
- Current Assignee: ARMAGEN, INC.
- Current Assignee Address: US CA Calabasas
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K16/18 ; C07K16/28 ; C12N9/16 ; A61K39/00
Abstract:
Provided herein are methods and compositions for treating a subject suffering from a deficiency in iduronate 2-sulfatase in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody that crosses the blood brain barrier (BBB) and an iduronate 2-sulfatase.
Public/Granted literature
- US20190185551A2 METHODS AND COMPOSITIONS FOR INCREASING IDURONATE 2-SULFATASE ACTIVITY IN THE CNS Public/Granted day:2019-06-20
Information query
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