Invention Grant
- Patent Title: HER2/neu-specific antibodies and methods of using same
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Application No.: US16156382Application Date: 2018-10-10
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Publication No.: US11028183B2Publication Date: 2021-06-08
- Inventor: Leslie S. Johnson , Ling Huang , Nadine Tuaillon , Ezio Bonvini
- Applicant: MacroGenics, Inc.
- Applicant Address: US MD Rockville
- Assignee: MacroGenics, Inc.
- Current Assignee: MacroGenics, Inc.
- Current Assignee Address: US MD Rockville
- Agency: AuerbachSchrot LLC
- Agent William C. Schrot; Jeffrey I. Auerbach
- Main IPC: C07K16/32
- IPC: C07K16/32 ; A61K39/395 ; A61K45/06 ; A61K39/00
Abstract:
This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.
Public/Granted literature
- US20190233539A1 HER2/neu-Specific Antibodies and Methods of Using Same Public/Granted day:2019-08-01
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