Invention Grant
- Patent Title: Compositions and methods for modulating an immune response
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Application No.: US15778524Application Date: 2016-11-23
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Publication No.: US11028364B2Publication Date: 2021-06-08
- Inventor: Peter T. Sage , Arlene H. Sharpe
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Foley Hoag LLP
- International Application: PCT/US2016/063604 WO 20161123
- International Announcement: WO2017/091729 WO 20170601
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; A61K35/26 ; A61K39/395 ; C07K16/00 ; A61K39/39 ; A61K39/00 ; C07K16/24
Abstract:
The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses and the use of those methods in the treatment of diseases or conditions such as viral, bacterial, pathogenic, or fungal infections or cancer. Such methods provide for boosting of antibody production through the use of IL-21 to overcome TFR cell suppression of antibody production.
Public/Granted literature
- US20180340147A1 COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE Public/Granted day:2018-11-29
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