Invention Grant
- Patent Title: Method for evaluating the risk of drug hypersensitivity reaction induced by Sulfamethoxazole and Trimethoprim
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Application No.: US16374651Application Date: 2019-04-03
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Publication No.: US11028437B2Publication Date: 2021-06-08
- Inventor: Wen-Hung Chung , Shuen-Iu Hung
- Applicant: Chang Gung Memorial Hospital, Linkou
- Applicant Address: TW Taoyuan
- Assignee: Chang Gung Memorial Hospital, Linkou
- Current Assignee: Chang Gung Memorial Hospital, Linkou
- Current Assignee Address: TW Taoyuan
- Agency: Pilloff Passino & Cosenza LLP
- Agent Sean A. Passino; Rachel K. Pilloff
- Main IPC: C12Q1/6874
- IPC: C12Q1/6874 ; C12Q1/02 ; C12Q1/6883

Abstract:
Provided is a method for evaluating the risk of drug hypersensitivity reaction induced by antibiotics sulfamethoxazole and/or trimethoprim. The drug hypersensitivity reaction comprises: maculopapular eruption, fixed drug eruption, Stevens-Johnson Syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms. A specific HLA genotype is associated with the drug hypersensitivity reaction induced by the antibiotics sulfamethoxazole and/or trimethoprim.
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