A computing system can be dynamically configured to operate with an eGPU that is connected to the computing system via a USB-C port. An eGPU manager, which may be a BIOS service, can be provided on a computing system and configured to detect when an eGPU has been connected to a USB-C port. When the eGPU manager detects an eGPU, it can employ an identifier of the eGPU and possibly characteristics of the eGPU and/or the computing system to query a lookup table for values for configuration settings that are optimal for the particular eGPU. The eGPU manager can then set the configuration settings to the obtained values so that the computing system will boot and/or operate properly while the eGPU is connected.