Invention Grant
- Patent Title: Transgenic chicken for production of antibodies having a common light chain
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Application No.: US15753938Application Date: 2016-08-24
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Publication No.: US11033009B2Publication Date: 2021-06-15
- Inventor: William Don Harriman , Robert Etches , Philip A. Leighton
- Applicant: Crystal Bioscience Inc.
- Applicant Address: US CA San Diego
- Assignee: Crystal Bioscience Inc.
- Current Assignee: Crystal Bioscience Inc.
- Current Assignee Address: US CA San Diego
- Agency: Bozicevic, Field & Francis LLP
- Agent James S. Keddie
- International Application: PCT/US2016/048485 WO 20160824
- International Announcement: WO2017/035274 WO 20170302
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C12N15/85 ; C07K16/00 ; C07K16/46

Abstract:
This disclosure provides, among other things, a transgenic animal and a method of using the same to make antibodies that have a common light chain. In certain embodiments, the transgenic animal may comprising a genome comprising a common light chain transgene, wherein the common light chain transgene comprises a non-immunoglobulin light-chain promoter and a common light-chain coding sequence. In certain embodiments, the common light chain is constitutively expressed.
Public/Granted literature
- US20180249687A1 TRANSGENIC ANIMAL FOR PRODUCTION OF ANTIBODIES HAVING A COMMON LIGHT CHAIN Public/Granted day:2018-09-06
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