The prosthesis for enterostomy patients comprises: a tubular element of elongated shape and insertable substantially to size inside of a stoma made on the abdominal wall of a patient; a first obstruction means to obstruct at least one area of the stoma, associated with a first end of the tubular element and movable between a restricted configuration and an enlarged configuration to allow the insertion/extraction into/from the stoma respectively, and to prevent leakage of feces from the stoma itself; a first through duct made on the tubular element, communicating with the first obstruction balloon and having valve connectable to a forced introduction/extraction disposable syringe for conduction of a fluid into/from the first obstruction balloon; a second through duct made on the tubular element, communicating with the inside of the stoma and having an active carbon filter for the outflow of gases from the stoma itself; and an external retaining element associated with a second end of the tubular element opposite to the first end and able to cooperate with at least one portion of the abdominal wall and having at least two through holes arranged at the first duct and the second duct; in which at least one of the tubular element and the retaining element is made at least partially of a flexible material.