Vitreoretinal instruments and methods related thereto are disclosed herein. The disclosure describes various example vitreoretinal instruments having various aspirating port configurations. A vitreoretinal instrument may include a handle and a cannula coupled to the handle. The cannula may include a straight portion and a curved portion. The curved portion may be configurable between a straight configuration and a curved configuration. The curved configuration may include a first curved portion having a curvature defined by a first radius. The curved configuration may include a second curved portion having a curvature defined by a second radius different from the first radius. The curved portion may further include one or more ports formed in the curved portion.