Invention Grant
- Patent Title: Polymer conjugate of hexa-coordinated platinum complex
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Application No.: US16431811Application Date: 2019-06-05
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Publication No.: US11033577B2Publication Date: 2021-06-15
- Inventor: Masaharu Nakamura , Tsuyoshi Fukuda , Yusaku Kikuchi , Chihiro Watanabe
- Applicant: Nippon Kayaku Kabushiki Kaisha
- Applicant Address: JP Tokyo
- Assignee: Nippon Kayaku Kabushiki Kaisha
- Current Assignee: Nippon Kayaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Nields, Lemack & Frame, LLC
- Priority: JPJP2015-180875 20150914
- Main IPC: A61K33/24
- IPC: A61K33/24 ; C07F15/00 ; C08G65/333 ; C08G65/337 ; C08G69/10 ; C08G69/40 ; C08G69/48 ; A61P35/00 ; A61K47/10 ; A61K47/34

Abstract:
A DDS preparation of a platinum complex, which selectively releases a highly active platinum complex in cells that are under reducing conditions, and exhibits high antitumor activity that is required from a medicine, is still not available, and there is a demand for a novel DDS preparation of a platinum complex that may be used in clinical fields. There is provided a polymer conjugate of a hexa-coordinated platinum complex, the polymer conjugate comprising a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety; and a hexa-coordinated platinum complex having a halogen atom and a hydroxyl group at the axial positions, the hexa-coordinated platinum complex being bonded, directly or via a spacer, to a side-chain carboxyl group of the block copolymer.
Public/Granted literature
- US20190282612A1 Polymer Conjugate Of Hexa-Coordinated Platinum Complex Public/Granted day:2019-09-19
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