Invention Grant
- Patent Title: Dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection
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Application No.: US16360970Application Date: 2019-03-21
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Publication No.: US11034730B2Publication Date: 2021-06-15
- Inventor: Frederic Tangy , Anavaj Sakuntabhai , Etienne Simon-Loriere , Claude Roth , Philippe Buchy
- Applicant: INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT PASTEUR DU CAMBODGE
- Applicant Address: FR Paris; FR Paris; KH Phnom-Penh
- Assignee: INSTITUT PASTEUR,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,INSTITUT PASTEUR DU CAMBODGE
- Current Assignee: INSTITUT PASTEUR,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,INSTITUT PASTEUR DU CAMBODGE
- Current Assignee Address: FR Paris; FR Paris; KH Phnom-Penh
- Agency: Arrigo, Lee, Guttman & Mouta-Bellum LLP
- Priority: EP14305984 20140623
- Main IPC: C07K14/005
- IPC: C07K14/005 ; A61K39/12 ; C12N7/00 ; C07K14/18 ; A61K39/00
Abstract:
The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection. The present invention provides means, in particular polynucleotides, vectors, cells and methods to produce vectors expressing said chimeric polyepitopes, in particular vectors consisting of recombinant measles virus (MV) particles. The present invention also relates to the use of the recombinant MV particles, in particular under the form of a composition or of a vaccine, for the prevention and/or treatment of a dengue virus infection.
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