Invention Grant
- Patent Title: Ligand-guided phagocytosis based therapy for treatment of Alzheimer's disease and other neurodegenerative diseases
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Application No.: US15774935Application Date: 2016-11-11
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Publication No.: US11034739B2Publication Date: 2021-06-15
- Inventor: Nora Blanca Caberoy
- Applicant: The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University of Nevada
- Applicant Address: US NV Las Vegas
- Assignee: The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University of Nevada
- Current Assignee: The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University of Nevada
- Current Assignee Address: US NV Las Vegas
- Agency: Ballard Spahr LLP
- International Application: PCT/US2016/061605 WO 20161111
- International Announcement: WO2017/083700 WO 20170518
- Main IPC: C07K14/47
- IPC: C07K14/47 ; A61K38/00 ; A61P25/28 ; C07K14/745 ; C07K16/24 ; C07K16/28

Abstract:
Disclosed are conjugates and compositions comprising an amyloid beta binding protein conjugated to a MerTK ligand. Disclosed are methods of clearing amyloid beta aggregates from a subject comprising administering a therapeutically effective amount of the conjugates and compositions comprising an amyloid beta binding protein conjugated to a MerTK ligand. Disclosed are methods of treating Alzheimer's Disease comprising administering to a subject in need thereof a therapeutically effective amount of conjugates and compositions comprising an amyloid beta binding protein conjugated to a MerTK ligand.
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