Invention Grant
- Patent Title: High affinity MAGE-A1-specific TCRs and uses thereof
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Application No.: US16571013Application Date: 2019-09-13
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Publication No.: US11034748B2Publication Date: 2021-06-15
- Inventor: Aude Chapuis , Thomas Schmitt , Megan McAfee
- Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
- Applicant Address: US WA Seattle
- Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
- Current Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
- Current Assignee Address: US WA Seattle
- Agency: Seed IP Law Group LLP
- Main IPC: A61K35/17
- IPC: A61K35/17 ; A61K39/00 ; A61P35/00 ; A61P35/02 ; C07K14/00 ; C07K14/705 ; C07K14/725 ; C12N5/0783
Abstract:
The present disclosure provides TCRs with high or enhanced affinity against various tumor associated antigens (including human MAGE-A1 epitopes), T cells expressing such high affinity antigen-specific TCRs, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells overexpress one or more of these antigens, such as in cancer.
Public/Granted literature
- US20200017568A1 HIGH AFFINITY MAGE-A1-SPECIFIC TCRS AND USES THEREOF Public/Granted day:2020-01-16
Information query
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