A tube pump system is provided, which includes a pair of roller units which are rotated around the axis line from a contact position to a separate position in a state where the pair of roller units compress the tube, a pair of drive units which rotate the pair of roller units respectively, and a control unit which controls each of the pair of drive units, wherein the control unit controls each of the pair of drive units such that, when one of the pair of roller units passes the separate position, an angular velocity of the other of the pair of roller units toward the separate position is gradually decreased.