Invention Grant
- Patent Title: Use of mild electrophiles to reduce artifacts in analyzing glycans released from glycoproteins or glycopeptides
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Application No.: US16322900Application Date: 2017-08-16
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Publication No.: US11035862B2Publication Date: 2021-06-15
- Inventor: Michael J. Kimzey
- Applicant: ProZyme, Inc.
- Applicant Address: US CA Hayward
- Assignee: ProZyme, Inc.
- Current Assignee: ProZyme, Inc.
- Current Assignee Address: US CA Hayward
- Agency: Hyman IP Law
- Agent Laurence J. Hyman
- International Application: PCT/US2017/047229 WO 20170816
- International Announcement: WO2018/035271 WO 20180222
- Main IPC: G01N33/58
- IPC: G01N33/58 ; G01N33/68 ; G01N33/53 ; C09B19/00 ; C09B57/02 ; C09B57/08 ; C12P19/04
Abstract:
The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or glycopeptides.
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