A computer-implemented method includes detecting a change in a spatial configuration of a plurality of sensors coupled to an unmanned aerial vehicle (UAV) based on a first set of sensor data from a plurality of sensors, generating one or more calibration instructions to cause the UAV to move along a predetermined pattern in response to detecting the change in the spatial configuration, and determining a subsequent spatial configuration of the plurality of sensors based at least in part on a second set of sensor data from the plurality of sensors. The second set of sensor data is collected by the plurality of sensors when the UAV is moving along the predetermined pattern.