An autonomous music composition and performance system employing an automated music composition and generation engine configured to receive musical signals from a set of a real or synthetic musical instruments being played by a group of human musicians. The system buffers and analyzes musical signals from the set of real or synthetic musical instruments, composes and generates music in real-time that augments the music being played by the band of musicians, and/or composes and generates music for subsequent playback, review and consideration by the human musicians.