An electronic system such as an imaging system may include processing circuitry and memory circuitry. The memory circuitry may include one-time-programmable memory having error correction code functionalities (e.g., SECDED functionalities). The one-time-programmable memory may have a first set of previously programmed bits and a second set of unprogrammed and unused bits. The processing circuitry may process instructions to update a bit in the second set of bits. To preserve the ECC functionalities (e.g., the ECC check bits associated with the first and second sets of bits, the processing circuitry may also update additional bits in the second set of bits.