A data center regulates supply air provided to multiple compartments including an information technology (IT) compartment having a cold aisle and a hot aisle and an operation technology (OT) compartment. An environmental subsystem of the data center includes an air handling system that provides supply air to the cold aisle and that draws return air from the hot aisle to moderate or cool a temperature of IT component(s) that may be installed within the IT compartment. Airflow regulation device(s) are positioned in at least one of (i) a supply air passage that guides a portion of the supply air in the cold aisle of the IT compartment into the OT compartment to moderate or cool a temperature of OT component(s) that may be installed within the OT compartment and/or (ii) a return air passage that guides air from the OT compartment(s) to the hot aisle of the IT compartment.