Invention Grant
- Patent Title: Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
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Application No.: US16478006Application Date: 2018-01-17
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Publication No.: US11040027B2Publication Date: 2021-06-22
- Inventor: Wolfgang Albrecht , Stefan Laufer , Roland Selig , Phillip Klövekorn , Bent Präfke
- Applicant: HEPAREGENIX GMBH
- Applicant Address: DE Ulm
- Assignee: HEPAREGENIX GMBH
- Current Assignee: HEPAREGENIX GMBH
- Current Assignee Address: DE Ulm
- Agency: Viksnins Harris Padys Malen LLP
- Priority: EP17151787 20170117,EP17204638 20171130
- International Application: PCT/EP2018/051110 WO 20180117
- International Announcement: WO2018/134254 WO 20180726
- Main IPC: A61K31/437
- IPC: A61K31/437 ; A61K31/501
Abstract:
The invention relates to MKK4 (mitogen-activated protein kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.
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