Invention Grant
- Patent Title: 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides
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Application No.: US16303539Application Date: 2017-05-23
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Publication No.: US11040035B2Publication Date: 2021-06-22
- Inventor: Norbert Schmees , Ilona Gutcher , Horst Irlbacher , Benjamin Bader , Na Zhao , Michael Platten , Ulrike Röhn , Ludwig Zorn , Lars Röse , Detlef Stöckigt
- Applicant: BAYER PHARMA AKTIENGESELLSCHAFT , DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ)
- Applicant Address: DE Berlin; DE Heidelberg
- Assignee: BAYER PHARMA AKTIENGESELLSCHAFT,DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ)
- Current Assignee: BAYER PHARMA AKTIENGESELLSCHAFT,DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ)
- Current Assignee Address: DE Berlin; DE Heidelberg
- Agency: Morrison & Foerster LLP
- Priority: WOPCT/CN2016/083308 20160525,WOPCT/CN2017/074408 20170222
- International Application: PCT/EP2017/062355 WO 20170523
- International Announcement: WO2017/202816 WO 20171130
- Main IPC: C07D237/14
- IPC: C07D237/14 ; C07D237/20 ; C07D401/10 ; C07D405/12 ; A61K31/501 ; A61P35/00 ; A61K31/50 ; A61K45/06 ; C07D237/24 ; C07D403/12

Abstract:
The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
Public/Granted literature
- US20200237757A1 3-OXO-2,6-DIPHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES Public/Granted day:2020-07-30
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