Invention Grant
- Patent Title: Compositions and methods for activating “stimulator of interferon gene”13 dependent signalling
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Application No.: US16659093Application Date: 2019-10-21
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Publication No.: US11040053B2Publication Date: 2021-06-22
- Inventor: George Edwin Katibah , David Kanne , Leonard Sung , Kelsey Gauthier , Laura Hix Glickman , Justin Leong , Sarah M. McWhirter , Thomas W. Dubensky, Jr.
- Applicant: CHINOOK THERAPEUTICS, INC.
- Applicant Address: US WA Seattle
- Assignee: CHINOOK THERAPEUTICS, INC.
- Current Assignee: CHINOOK THERAPEUTICS, INC.
- Current Assignee Address: US WA Seattle
- Agency: Acuity Law Group, PC
- Agent Michael A. Whittaker
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; A61K31/7084 ; C07H21/00 ; C07H21/02 ; A61P37/06 ; A61P11/06 ; A61P29/00 ; A61P3/10 ; A61P35/00 ; A61K39/39 ; C07H19/213
Abstract:
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′-fluoro substituted, bis-3′,5′ CDNs, and most preferably one or more 2′,2″-diF-Rp,Rp, bis-3′,5′CDNs.
Public/Granted literature
- US20200179431A1 COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE" - DEPENDENT SIGNALLING Public/Granted day:2020-06-11
Information query
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