An embodiment of the present disclosure is a sample collection unit configured to receive a test strip. The sample collection unit includes a collection tube including an open end and a cap configured to be coupled to the open end to close the collection tube. The cap includes an access opening that extends through the cap and at least one sealing member aligned with the access opening. The at least one sealing member includes a dynamic strip interface that permits insertion of the test strip through the access opening and into the collection tube.