Invention Grant
- Patent Title: Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
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Application No.: US16258640Application Date: 2019-01-27
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Publication No.: US11040938B2Publication Date: 2021-06-22
- Inventor: Bing Ma , Shuai Pan
- Applicant: SHANGHAI HYBRID—CHEM TECHNOLOGIES
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI HYBRID—CHEM TECHNOLOGIES
- Current Assignee: SHANGHAI HYBRID—CHEM TECHNOLOGIES
- Current Assignee Address: CN Shanghai
- Agency: WEN IP LLC
- Agent Zhihua Han
- Priority: CN201610602290.6 20160727,CN201710608662.0 20170724
- Main IPC: C07C243/22
- IPC: C07C243/22 ; B01J19/00 ; B01J19/24 ; C07C303/22 ; C07C241/02 ; C07C253/30

Abstract:
The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.
Public/Granted literature
- US20190152896A1 Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts Public/Granted day:2019-05-23
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