Invention Grant
- Patent Title: Substituted quinazolines as matrix metalloproteinase-9 hemopexin domain inhibitors
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Application No.: US16494984Application Date: 2018-03-22
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Publication No.: US11040947B2Publication Date: 2021-06-22
- Inventor: Iwao Ojima , Vincent Alford , Anushree Kamath , Jian Cao , Xiadong Ren , Nicole Sampson , Monaf Awwa
- Applicant: The Research Foundation for The State University of New York
- Applicant Address: US NY Albany
- Assignee: The Research Foundation for The State University of New York
- Current Assignee: The Research Foundation for The State University of New York
- Current Assignee Address: US NY Albany
- Agency: Hoffman & Baron, LLP
- International Application: PCT/US2018/023676 WO 20180322
- International Announcement: WO2018/175670 WO 20180927
- Main IPC: A61K31/517
- IPC: A61K31/517 ; C07D239/95 ; A61P35/00 ; C07D239/56 ; C07D403/12

Abstract:
A compound of Formula I: wherein: Y is —C(O)NHR1 or —NHC(O)R1; R1 is aryl; is optionally substituted with one or more substituents selected from the group consisting of oxo, F, Cl, Br, I, alkyl, NH2, NHR4, NHC(O)R4, NHC(O)OR4, NR5R6, OH, OR4, SR4, cycloalkyl and aryl; or is optionally substituted with one or more substituents selected from the group consisting of F, Cl, Br, I, CN, NO2, alkyl, C(O)R4, C(O)NHR4, C(O)NR5R6, C(O)OH, C(O)OR4, NH2, NHR4, NHC(O)OR4, NR5R6, OH, OR4, SR4, cycloalkyl and aryl; each R4 is independently alkyl, cycloalkyl, or aryl; each R5 is independently alkyl, cycloalkyl, or aryl; each R6 is independently alkyl, cycloalkyl, or aryl; or each R5 and R6, together with the nitrogen atom to which they are attached, independently form an unsubstituted heterocyclic alkyl or unsubstituted heterocyclic aryl; and X is —S— or —O—; and n is 2, 3, or 4.
Public/Granted literature
- US20200017452A1 MATRIX METALLOPROTEINASE-9 HEMOPEXIN DOMAIN INHIBITORS AND METHODS OF TREATMENT USING SAME Public/Granted day:2020-01-16
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