Invention Grant
- Patent Title: Methods and compositions relating to genotoxin colibactin
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Application No.: US16542583Application Date: 2019-08-16
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Publication No.: US11040951B2Publication Date: 2021-06-22
- Inventor: Matthew R. Volpe , Emily Patricia Balskus , Matthew Ryan Wilson
- Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Applicant Address: US MA Cambridge
- Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee Address: US MA Cambridge
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Nicole D. Kling
- Main IPC: C07D311/16
- IPC: C07D311/16 ; G01N33/58
Abstract:
The technology described herein is directed to compounds which are substrates for ClbP, acting as fluorescent probes for ClbP activity. Further provided herein are methods for measuring ClbP activity, screening for ClbP inhibitors, detecting colibactin, and/or diagnosing cancer, which utilize the substrate compounds.
Public/Granted literature
- US20200055836A1 METHODS AND COMPOSITIONS RELATING TO GENOTOXIN COLIBACTIN Public/Granted day:2020-02-20
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