Invention Grant
- Patent Title: Triazole antimicrobial derivative, pharmaceutical composition and use thereof
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Application No.: US16486761Application Date: 2018-02-08
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Publication No.: US11040958B2Publication Date: 2021-06-22
- Inventor: Hongwei Tang , Jun Lou , Penggao Yu , Li Liu , Anxiao Zheng , Yongkai Chen , Chaodong Wang
- Applicant: WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. , WUHAN QR PHARMACEUTICALS CO., LTD.
- Applicant Address: CN Hubei; CN Hubei
- Assignee: WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD.,WUHAN QR PHARMACEUTICALS CO., LTD.
- Current Assignee: WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD.,WUHAN QR PHARMACEUTICALS CO., LTD.
- Current Assignee Address: CN Hubei; CN Hubei
- Agency: Novick, Kim & Lee, PLLC
- Agent Allen Xue
- Priority: CN201710087041.2 20170217
- International Application: PCT/CN2018/075862 WO 20180208
- International Announcement: WO2018/149359 WO 20180823
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D403/06 ; C07F9/6558 ; C07H13/04 ; A61P31/10

Abstract:
The present disclosure provides a triazole antibacterial derivative and a pharmaceutical composition thereof and a use thereof and in particular relates to a compound represented by the following formula (I), and a racemate, a stereoisomer, a tautomer, an oxynitride or a pharmaceutically acceptable salt thereof: The compound of the present disclosure has a desirable water solubility and can be formulated into an injection for use without adding a cosolvent having a potential safety risk (such as hydroxypropyl-β-cyclodextrin, sulfobutylether-β-cyclodextrin, and the like), facilitating drug administration for patients, and greatly improving clinical safety. The drug can be used even by patients with moderate or severe renal impairment, thereby expanding the application scope of the drug.
Public/Granted literature
- US20190382375A1 TRIAZOLE ANTIMICROBIAL DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF Public/Granted day:2019-12-19
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