Invention Grant
- Patent Title: Piperazine derivatives for influenza virus inhibitions
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Application No.: US16483283Application Date: 2018-02-01
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Publication No.: US11040963B2Publication Date: 2021-06-22
- Inventor: Maria Van Dongen , Jaroslaw Juraszek , Griet Wim Bert Schepens , Charles Edward Lawson , Brian Shook , Maria Tim Hugo Jonckers , Abdellah Tahri , Bernard Pierre Jean-Marie Raboisson , Nestor CHristophe Francis Robert Buyck
- Applicant: JANSSEN VACCINES & PREVISION B.V.
- Applicant Address: NL Leiden
- Assignee: JANSSEN VACCINES & PREVISION B.V.
- Current Assignee: JANSSEN VACCINES & PREVISION B.V.
- Current Assignee Address: NL Leiden
- Agency: Kramer Amado, P.C.
- Priority: EP17156448 20170216
- International Application: PCT/EP2018/052537 WO 20180201
- International Announcement: WO2018/141854 WO 20180809
- Main IPC: C07D413/10
- IPC: C07D413/10 ; A61P31/16 ; C07D401/10 ; C07D413/14 ; C07D417/10 ; C07D417/14 ; C07D487/08 ; C07D498/04 ; C07D263/57 ; C07D413/12 ; C07D277/66 ; C07D417/12 ; C07D295/108 ; C07D307/79 ; C07D235/18
Abstract:
The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.
Public/Granted literature
- US20200010459A1 PIPERAZINE DERIVATIVES FOR INFLUENZA VIRUS INHIBITIONS Public/Granted day:2020-01-09
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