Invention Grant
- Patent Title: Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof
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Application No.: US16432469Application Date: 2019-06-05
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Publication No.: US11040978B2Publication Date: 2021-06-22
- Inventor: Kassoum Nacro , Athisayamani Jeyaraj Duraiswamy , Lohitha Rao Chennamaneni
- Applicant: Agency for Science, Technology, and Research
- Applicant Address: SG Singapore
- Assignee: Agency for Science, Technology, and Research
- Current Assignee: Agency for Science, Technology, and Research
- Current Assignee Address: SG Singapore
- Agency: Thomas|Horstemeyer LLP
- Priority: GB1205669 20120330
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D235/06 ; C07D471/04 ; C07D519/00 ; A61K45/06 ; A61K31/4184 ; A61K31/437 ; A61K31/4985 ; A61K31/5025 ; A61K31/519 ; A61P35/00 ; A61K31/4545 ; A61K31/496 ; A61K31/5377 ; A61K31/551 ; A61K31/553 ; C07D471/10 ; C07D491/107
Abstract:
The present invention relates to compounds of Formula (Ib-I) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, Alzheimer's disease), as well as methods of treating these diseases.
Public/Granted literature
- US20190315755A1 BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF Public/Granted day:2019-10-17
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