Invention Grant
- Patent Title: Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
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Application No.: US16708340Application Date: 2019-12-09
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Publication No.: US11040980B2Publication Date: 2021-06-22
- Inventor: Tim Owens , Erik Verner
- Applicant: PRINCIPIA BIOPHARMA INC.
- Applicant Address: US CA South San Francisco
- Assignee: PRINCIPIA BIOPHARMA INC.
- Current Assignee: PRINCIPIA BIOPHARMA INC.
- Current Assignee Address: US CA South San Francisco
- Agency: McNeill Baur PLLC
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D487/04 ; C07D519/00 ; A61K31/495 ; A61K31/506 ; C07D401/14 ; C07D403/12 ; C07D405/12 ; A61K31/5377 ; A61K45/06 ; A61K9/00
![Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors](/abs-image/US/2021/06/22/US11040980B2/abs.jpg.150x150.jpg)
Abstract:
The present disclosure provides compounds of Formula (IA), such as, e.g., (R)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile having the chemical structure and/or pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BTK inhibitors, and are potentially useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer, inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and/or pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.
Information query
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