Invention Grant
- Patent Title: Identification of mutations in channelopsin variants having improved light sensitivity and methods of use thereof
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Application No.: US16328916Application Date: 2017-08-29
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Publication No.: US11041004B2Publication Date: 2021-06-22
- Inventor: Zhuo-Hua Pan
- Applicant: Wayne State University
- Applicant Address: US MI Detroit
- Assignee: Wayne State University
- Current Assignee: Wayne State University
- Current Assignee Address: US MI Detroit
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- International Application: PCT/US2017/049158 WO 20170829
- International Announcement: WO2018/044912 WO 20180308
- Main IPC: C07K14/405
- IPC: C07K14/405 ; A61P27/02 ; A61K38/00 ; A61K35/00
Abstract:
The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant CoChop protein. Methods of the invention include administering a composition comprising a mutant CoChop to a subject to preserve, improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject having impaired vision, thereby restoring vision to normal levels.
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