Invention Grant
- Patent Title: Mycobacteriophages capable of delivering auto-luminescent elements and uses thereof
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Application No.: US16124252Application Date: 2018-09-07
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Publication No.: US11041184B2Publication Date: 2021-06-22
- Inventor: Tianyu Zhang , Zhiyong Liu
- Applicant: GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Guangdong
- Assignee: GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES
- Current Assignee: GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Guangdong
- Priority: CN201610127984.9 20160307
- Main IPC: C12Q1/18
- IPC: C12Q1/18 ; C12Q1/04 ; C12N15/10 ; C12N15/73 ; C12Q1/689 ; C12Q1/70 ; C12N15/70 ; C12N15/74 ; C12Q1/02
Abstract:
A mycobacteriophage capable of delivering an auto-luminescent element includes luxCDABE genes for auto-luminescence of a host bacterium. The auto-luminescent element is located on a transposon, and can be randomly inserted into the host genome with the transposon. The mycobacteriophage can be used for rapid detection of a live host bacterium in a sample and detection of sensitivity of the host bacterium to a drug or drug combination.
Public/Granted literature
- US20190040445A1 MYCOBACTERIOPHAGES CAPABLE OF DELIVERING AUTO-LUMINESCENT ELEMENTS AND USES THEREOF Public/Granted day:2019-02-07
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