A novel sealing member and a novel wedging element that may be part of a novel seal assembly. The seal assembly may remain effective for more connection/disconnection cycles as compared to the previously known seals. In exemplary embodiments, the wedging element may engage the sealing member or a pair of the sealing members that sandwich the wedging element. When engaged, an inclined surface of the wedging element may radially compress a radially inwardly extending sealing leg of one or both of the sealing members. A fluid pressure opposite the wedging element relative to the corresponding sealing member may radially expand a radially outwardly extending sealing leg of one or both of the sealing members.