A device for inspecting tires of large dimensions, in particular for civil engineering vehicles, comprises: a rotationally driven tire support (10) designed to support a tire (20) to be inspected in position so that its axis of rotation is substantially horizontal, said support comprising means for rotating the supported tire; an ultrasound inspection device (1) provided with an inspection head (5) that is freely mounted radially and axially, a module (8) for retrieving and processing echo data retrieved during inspection phases, and a system for controlling the movement of the inspection head (5) inside the tire to be inspected, in particular along the inner wall of the crown area of said tire to be inspected.