Sensor devices, hand-held probes and systems for use in detection of one or more analyte(s) are presented. The sensor device comprises at least one sensing unit and a measurement unit. The sensing unit comprises a surface by which the sensing unit is exposed to a media when the sensor device is in use, the surface carrying one or more carbohydrate-based compositions immobilized thereon, the carbohydrate-based composition comprises one or more of the following: oxidized cellulose, nano-cellulose, regenerated cellulose, crystalline cellulose and amorphous cellulose, the sensing unit having one or more of its parameters changeable in response to binding between the carbohydrate-based composition and one or more carbohydrate binding modules (CBM) of CBM-containing analyte(s) in the media. The measurement unit being configured and operable to monitor one or more of the parameter(s) of the sensing unit, and upon detecting a change in one of the one or more parameter(s) generating sensing data indicative of the change, thereby enabling detection of the one or more CBM-containing analytes in the media.