The present disclosure discloses a driving method for pulse width and voltage hybrid modulation, a driving device and a display device, the method including: after receiving a frame image to be displayed, generating N sub-frame images from the received frame image to be displayed; then controlling a display panel to display each sub-frame image in turn, and controlling, when each sub-frame image is displayed, the sub-pixel that needs to emit light in the sub-frame image to emit light according to the corresponding light-emitting brightness in the light-emitting period corresponding to the sub-frame image. In one sub-frame image, the light-emitting brightness of the sub-pixel is determined by the display brightness corresponding to the sub-pixel in the frame image to be displayed, and the light-emitting time configured for the sub-frame image.