Invention Grant
- Patent Title: Nanoparticle comprising a bio-resorbable polyester, a hydrophilic polymer and an acylated human lactoferrin-derived peptide
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Application No.: US17052947Application Date: 2019-04-24
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Publication No.: US11052053B2Publication Date: 2021-07-06
- Inventor: Roland Brock , Rike Nabbefeld , Silko Grimm , Anne Benedikt , Andrea Engel , Alexander Henrik Baron van Asbeck , Jürgen Dieker
- Applicant: Evonik Operations GmbH
- Applicant Address: DE Essen
- Assignee: Evonik Operations GmbH
- Current Assignee: Evonik Operations GmbH
- Current Assignee Address: DE Essen
- Agency: Grüneberg and Myers PLLC
- Priority: EP18171195 20180508
- International Application: PCT/EP2019/060410 WO 20190424
- International Announcement: WO2019/214939 WO 20191114
- Main IPC: A61K9/51
- IPC: A61K9/51 ; A61K9/50 ; A61K9/14 ; A61K49/00

Abstract:
A nanoparticle includes a core. The core includes a bio-resorbable polyester and a hydrophilic polymer. The hydrophilic polymer is a portion of the bio-resorbable polyester or a separate polymer. An acylated human lactoferrin-derived peptide is coated onto the core. The acylated human lactoferrin-derived peptide is a peptide with the amino acid sequence SEQ ID NO. 1: KCFQWQRNMRKVRGPPVSCIKR or an amino acid sequence, which does not differ by more than 8 amino acid positions from the sequence SEQ ID NO: 1. The N-terminus of the human lactoferrin-derived peptide is acylated with a C16-monoacyl group.
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