Invention Grant
- Patent Title: Kinase inhibitors and methods of use thereof
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Application No.: US16198589Application Date: 2018-11-21
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Publication No.: US11052080B2Publication Date: 2021-07-06
- Inventor: Florence Fevrier Wagner , Jennifer Q. Pan , Sivaraman Dandapani , Andrew Germain , Edward Holson , Benito Munoz , Partha P. Nag , Michael C. Lewis , Stephen J. Haggarty , Joshua A. Bishop , Kimberly Stegmaier , Michel Weiwer , Versha Banerji
- Applicant: The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation
- Applicant Address: US MA Cambridge; US MA Boston; US MA Boston
- Assignee: The Broad Institute, Inc.,Dana-Farber Cancer Institute, Inc.,The General Hospital Corporation
- Current Assignee: The Broad Institute, Inc.,Dana-Farber Cancer Institute, Inc.,The General Hospital Corporation
- Current Assignee Address: US MA Cambridge; US MA Boston; US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D471/10 ; A61K31/4745 ; A61K31/4747
Abstract:
The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.
Public/Granted literature
- US20200061050A9 KINASE INHIBITORS AND METHODS OF USE THEREOF Public/Granted day:2020-02-27
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