methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating autoimmune diseases](/docs/US/2021-07-06/US11052092B2/abs.jpg.600x600.jpg)
- Patent Title: N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating autoimmune diseases
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Application No.: US16481233Application Date: 2018-01-29
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Publication No.: US11052092B2Publication Date: 2021-07-06
- Inventor: Jean-Francois Delhomel , Enrico Perspicace , Zouher Majd , Peggy Parroche , Robert Walczak
- Applicant: Genfit
- Applicant Address: FR Loos
- Assignee: Genfit
- Current Assignee: Genfit
- Current Assignee Address: FR Loos
- Agency: Cesari & McKenna, LLP
- Priority: EP17305093 20170127,EP17178888 20170629
- International Application: PCT/EP2018/052172 WO 20180129
- International Announcement: WO2018/138362 WO 20180802
- Main IPC: C07D215/227
- IPC: C07D215/227 ; A61K31/536 ; A61P37/02 ; A61K31/192 ; A61K31/357 ; A61K31/39 ; A61K31/40 ; A61K31/405 ; A61K31/428 ; A61K31/4439 ; A61K31/454 ; A61K31/47 ; A61K31/4709 ; A61K31/498 ; A61K31/5377 ; C07D401/12 ; C07D405/12 ; C07D405/14 ; C07D407/12 ; C07D411/12 ; C07D411/14 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D417/14
methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating autoimmune diseases](/abs-image/US/2021/07/06/US11052092B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides e.g. N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating e.g. autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases or cholestatic diseases, such as e.g. arthitis and asthma.
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